In Fertility Treatment

Personalized fertility medicine

Introducing Simbryo FX, the first functional test of your endometrium's ability to accept an embryo.

Using your own stem cells from a routine endometrial biopsy, we grow a living model of your endometrium in the lab. An endometrial organoid = your uterus in a dish. We challenge the organoid with blastoids (artificial embryos) and measure the response.

Blastoid implantation

hCG, the same hormone measured by a pregnancy test, is produced by the implanted blastoid and implantation is observed directly in the organoid.

hCG detected

No blastoid implantation

hCG is not produced and implantation is not observed, both signs of endometrial dysfunction.

No hCG detected

Why Simbryo

We developed Simbryo to bring you answers.

Simbryo is the first endometrial fertility platform designed to make your next step clearer. By analyzing your own endometrial tissue, Simbryo reveals how your body may support implantation.

What you'll learn

If your Simbryo score is high

If you experienced failed transfers or have just a few embryos left, you're facing high-stakes decisions. And we know how hard that is.

While pregnancy can never be guaranteed, your Simbryo score tells you that your endometrium is working, and with good embryos, you have an excellent chance of success. Go for it and don't give up.

If your Simbryo score is low

If you weren't successful previously, you probably weren't just unlucky.

Your Simbryo score tells you that your endometrium isn't optimal, and knowing that helps you gear up physically, emotionally, and financially for a potentially longer journey ahead. Recurrent Implantation Failure, a condition where the endometrium won't accept a good embryo even after many tries, is relatively rare. But if you've already experienced unsuccessful transfers or you only have a few embryos and can't afford multiple attempts, your low Simbryo score may point you to surrogacy or alternative treatments. You have options to consider.

Ready to find answers?

Get started →

Prefer to talk it through first? Book time →

How Simbryo works

Simbryo uses an endometrial biopsy — a quick, in-office procedure.

STEP 01

Your doctor collects a small endometrial sample.

STEP 02

Simbryo Labs receives your sample and runs testing.

STEP 03

You and your doctor receive personalized reports.

Menu of available tests

A complete panel of endometrial tests from a single biopsy.

An all-in-one solution that's convenient and cost effective.

SIMBRYO / fx

The core test

The world's first direct measure of endometrial function.

Available add-ons

SIMBRYO / screen

Tissue pathology screen.

SIMBRYO / immuno

Evaluation of endometritis and inflammation.

SIMBRYO / micro

Endometrial microbiome analysis.

SIMBRYO / endo

Endometriosis biomarker test.

SIMBRYO / omics

Window of implantation test.

SIMBRYO / bank

Request to bank your sample.

We store it for up to a year — no new biopsy needed when you're ready.

You and your physician select the appropriate tests to provide a comprehensive picture of how your endometrial fertility may affect embryo transfer and to guide your fertility journey with greater confidence.

Request Simbryo →

Patient stories

Breakthrough science, trusted by experts.

Simbryo is used by hundreds of people with unexplained infertility and embryo transfer failure.

I came to my doctor trying to find answers to why I had 4 repeated implantation failures. We decided to do an endometrial biopsy to submit to Simbryo for testing. The results came back normal, and I got pregnant. This was a complete shock because I had been recommended by two other doctors to move on to surrogacy, which I just wasn't ready for.

Jill, 42, Denver — Simbryo patient

Developed through research and clinical studies at leading universities and fertility centers.

Act now

Take control of your fertility journey.

Simbryo FX is helping patients like you get the answers they need to make better fertility decisions. Ready to take the next step? Talk with your doctor about ordering Simbryo, or we can help find a partner clinic near you.