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With good embryos, problems with the endometrium are the leading cause. But they are often silent, discovered only through repeated failure to conceive.
A healthy, euploid embryo still fails to implant about one third of the time. When it does, the conversation almost always returns to the embryo — its grade, its genetics, the next transfer.
But an embryo doesn't implant into a vacuum. It implants into endometrial tissue — a living surface that has to be ready to receive it. For most of IVF's history, that surface has been treated as a backdrop instead of a variable.
Advances in stem cell technology make it possible to understand the endometrium for the first time.
Leveraging a routine biopsy, we use create an endometrial organoid, a living, miniature model of the uterine lining from the patients own stem cells that we can test, perturb, and read.
This is a novel functional tests of the uterine lining — not a snapshot of which genes are on, but a measure of how the tissue actually behaves. That's the other half of the pregnancy equation. And it's the half we're here to bring into focus.
Based on over 20 years of research by the world's leading scientists. We are stem cell biologists, fertility specialists, and AI technologists, and we created Simbryo to revolutionize the fertility experience for the next generation of parents.
Meet the team →Simbryo is backed by investors and institutions across bio tech, deep tech, consumer products, women's health, and health care delivery — partners who share our conviction that unexplained is unacceptable and we need to do better.
View investors →Announcements, milestones, and press coverage as we work to transform the fertility space through organoid medicine and AI. For interviews, data, or imagery, our team is one email away.
Visit newsroom →Simbryo Technologies is a commercial-stage biotech company accelerating paths to pregnancy via organoid medicine and AI. Working with top research institutions and fertility clinics, Simbryo develops personalized diagnostic platforms that predict and optimize endometrial fertility, giving patients and physicians actionable insights to increase success rates and providing a powerful in-vitro test bed for novel fertility treatments.
We'd love to connect with partners who share our conviction. Reach out and we'll be in touch.