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Even with a perfect embryo, pregnancy isn't guaranteed. Until now, there's been no scientifically robust way to measure endometrial fertility. No way to distinguish chance failure from endometrial dysfunction and tell in advance who is likely to be successful from who will likely face a long road.
Not knowing what to expect results in patients hesitating to start treatment, dropping out when they experience a setback, and being dissatisfied with their care. For the first time, Simbryo provides a measure of endometrial fertility, giving you and your patients the confidence to move forward with treatment.
Imagine if we could simulate implantation in the lab before embryo transfer. Simbryo uses a patient's own biopsy tissue to grow an organoid model of their endometrium and test whether it is capable of implantation in vitro.
Organoids are treated with estrogen and progesterone to mimic the menstrual cycle.
Blastoids (synthetic blastocysts) implant in the organoids of fertile patients, but not in those with endometrial problems.
Receptivity is quantified via hCG secretion of implanted blastoids and tissue imaging.
Provide the most advanced success prediction with Simbryo precision diagnostics.
Simbryo assesses your patients' endometrial fertility and combines it with their clinical and reproductive profile, delivering the most complete prognosis so they can move forward with confidence.
Rule out endometrial dysfunction and retain patients, especially after a setback.
While pregnancy can never be guaranteed, patients with a normal Simbryo score can feel reassured that they have an excellent chance of success and should stick with treatment.
Help your patients plan for the journey ahead, keeping them on the course.
A negative result when you expect success feels crushing. A negative result when you know the odds are long feels expected. Knowing what to expect lets patients plan ahead, giving them the wherewithal to stick with treatment.
Identify patients with poor prognosis and help them move to alternative treatment sooner.
Recurrent implantation failure is relatively rare, but identifying it before a patient undergoes multiple failed cycles enables you to guide them toward alternative treatments or surrogacy sooner, before wasting valuable embryos, time, money, and emotional reserve.
Run multiple tests from a single biopsy sample — convenient and cost effective for you and your patients.
Get started immediately with an easy, integrated workflow and dedicated support.
Option to bank endometrial biopsy samples taken during hysteroscopy or egg retrieval if the patient isn't ready for Simbryo testing now.
Biopsy can be taken at any point in the cycle — mock cycle not required.
Automated courier pickup in the US, with international shipping available.
Reports are sent to your clinic for easy sharing with your patients.
"The Simbryo workflow is wonderful! Quick and easy!"
Madhuri Pingle Texas Fertility Center
Order a single test, complete panel, or custom selection.
The world's first direct measure of endometrial function, leveraging organoid medicine.
When patients experience embryo transfer failure, they want answers. The Simbryo platform gives physicians personalized insight into endometrial fertility, enabling them to better guide patients.
We have made great strides optimizing the embryo side of IVF, but the endometrium has remained much more difficult. Identifying why implantation is not successful is groundbreaking.
Developed through research and clinical studies at leading universities and fertility centers.
